RGS9-2–controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

The striatal protein Regulator of G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protein–coupled receptor responses. Here, we use the murine spared-nerve injury model of neuropathic pain to investigate the mechanism by which RGS9-2 in the nucleus accum...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mitsi, Vasiliki, Terzi, Dimitra, Purushothaman, Immanuel, Manouras, Lefteris, Gaspari, Sevasti, Neve, Rachael L., Stratinaki, Maria, Feng, Jian, Shen, Li, Zachariou, Venetia
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568688/
https://ncbi.nlm.nih.gov/pubmed/26305935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504283112
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