Allosteric activation of apicomplexan calcium-dependent protein kinases

Calcium-dependent protein kinases (CDPKs) comprise the major group of Ca(2+)-regulated kinases in plants and protists. It has long been assumed that CDPKs are activated, like other Ca(2+)-regulated kinases, by derepression of the kinase domain (KD). However, we found that removal of the autoinhibito...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Ingram, Jessica R., Knockenhauer, Kevin E., Markus, Benedikt M., Mandelbaum, Joseph, Ramek, Alexander, Shan, Yibing, Shaw, David E., Schwartz, Thomas U., Ploegh, Hidde L., Lourido, Sebastian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568647/
https://ncbi.nlm.nih.gov/pubmed/26305940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505914112
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