[Formula: see text] triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

Neural activity is accompanied by a transient mismatch between local glucose and oxygen metabolism, a phenomenon of physiological and pathophysiological importance termed aerobic glycolysis. Previous studies have proposed glutamate and K(+) as the neuronal signals that trigger aerobic glycolysis in...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lerchundi, Rodrigo, Fernández-Moncada, Ignacio, Contreras-Baeza, Yasna, Sotelo-Hitschfeld, Tamara, Mächler, Philipp, Wyss, Matthias T., Stobart, Jillian, Baeza-Lehnert, Felipe, Alegría, Karin, Weber, Bruno, Barros, L. Felipe
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568276/
https://ncbi.nlm.nih.gov/pubmed/26286989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508259112
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