Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains

The extended rod-like Plasmodium falciparum circumsporozoite protein (CSP) is comprised of three primary domains: a charged N terminus that binds heparan sulfate proteoglycans, a central NANP repeat domain, and a C terminus containing a thrombospondin-like type I repeat (TSR) domain. Only the last t...

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Pubblicato in:Infect Immun
Autori principali: Herrera, Raul, Anderson, Charles, Kumar, Krishan, Molina-Cruz, Alvaro, Nguyen, Vu, Burkhardt, Martin, Reiter, Karine, Shimp, Richard, Howard, Randall F., Srinivasan, Prakash, Nold, Michael J., Ragheb, Daniel, Shi, Lirong, DeCotiis, Mark, Aebig, Joan, Lambert, Lynn, Rausch, Kelly M., Muratova, Olga, Jin, Albert, Reed, Steven G., Sinnis, Photini, Barillas-Mury, Carolina, Duffy, Patrick E., MacDonald, Nicholas J., Narum, David L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
Soggetti:
Fungal and Parasitic Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567636/
https://ncbi.nlm.nih.gov/pubmed/26169272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.02676-14
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