Acylation Enhances, but Is Not Required for, the Cytotoxic Activity of Mannheimia haemolytica Leukotoxin in Bighorn Sheep

Mannheimia haemolytica causes pneumonia in domestic and wild ruminants. Leukotoxin (Lkt) is the most important virulence factor of the bacterium. It is encoded within the four-gene lktCABD operon: lktA encodes the structural protoxin, and lktC encodes a trans-acylase that adds fatty acid chains to i...

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Detaylı Bibliyografya
Yayımlandı:Infect Immun
Asıl Yazarlar: Batra, Sai A., Shanthalingam, Sudarvili, Munske, Gerhard R., Raghavan, Bindu, Kugadas, Abirami, Bavanthasivam, Jegarubee, Highlander, Sarah K., Srikumaran, Subramaniam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Molecular Pathogenesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567630/
https://ncbi.nlm.nih.gov/pubmed/26216418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00733-15
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