Acylation Enhances, but Is Not Required for, the Cytotoxic Activity of Mannheimia haemolytica Leukotoxin in Bighorn Sheep

Mannheimia haemolytica causes pneumonia in domestic and wild ruminants. Leukotoxin (Lkt) is the most important virulence factor of the bacterium. It is encoded within the four-gene lktCABD operon: lktA encodes the structural protoxin, and lktC encodes a trans-acylase that adds fatty acid chains to i...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Batra, Sai A., Shanthalingam, Sudarvili, Munske, Gerhard R., Raghavan, Bindu, Kugadas, Abirami, Bavanthasivam, Jegarubee, Highlander, Sarah K., Srikumaran, Subramaniam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567630/
https://ncbi.nlm.nih.gov/pubmed/26216418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00733-15
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