Acylation Enhances, but Is Not Required for, the Cytotoxic Activity of Mannheimia haemolytica Leukotoxin in Bighorn Sheep

Mannheimia haemolytica causes pneumonia in domestic and wild ruminants. Leukotoxin (Lkt) is the most important virulence factor of the bacterium. It is encoded within the four-gene lktCABD operon: lktA encodes the structural protoxin, and lktC encodes a trans-acylase that adds fatty acid chains to i...

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Bibliografiska uppgifter
I publikationen:Infect Immun
Huvudupphovsmän: Batra, Sai A., Shanthalingam, Sudarvili, Munske, Gerhard R., Raghavan, Bindu, Kugadas, Abirami, Bavanthasivam, Jegarubee, Highlander, Sarah K., Srikumaran, Subramaniam
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Molecular Pathogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567630/
https://ncbi.nlm.nih.gov/pubmed/26216418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00733-15
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