Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

Invading viral DNA can be recognized by the host cytosolic DNA sensor, cyclic GMP-AMP (cGAMP) synthase (cGAS), resulting in production of the second messenger cGAMP, which directs the adaptor protein STING to stimulate production of type I interferons (IFNs). Although several DNA viruses are sensed...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Wu, Jian-jun, Li, Wenwei, Shao, Yaming, Avey, Denis, Fu, Bishi, Gillen, Joseph, Hand, Travis, Ma, Siming, Liu, Xia, Miley, Wendell, Konrad, Andreas, Neipel, Frank, Stürzl, Michael, Whitby, Denise, Li, Hong, Zhu, Fanxiu
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567405/
https://ncbi.nlm.nih.gov/pubmed/26320998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.07.015
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