Highly Selective Anti-Cancer Activity of Cholesterol-Interacting Agents Methyl-β-Cyclodextrin and Ostreolysin A/Pleurotolysin B Protein Complex on Urothelial Cancer Cells

Cholesterol content can vary distinctly between normal and cancer cells, with elevated levels in cancer cells. Here, we investigated cholesterol sequestration with methyl-β-cyclodextrin (MCD), and pore-formation with the ostreolysin A/pleurotolysin B (OlyA/PlyB) protein complex that binds to cholest...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Resnik, Nataša, Repnik, Urška, Kreft, Mateja Erdani, Sepčić, Kristina, Maček, Peter, Turk, Boris, Veranič, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567298/
https://ncbi.nlm.nih.gov/pubmed/26361392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137878
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