Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation

PURPOSE: We tested whether 18 polymorphisms in 16 genes (GSTP1, COX2, IL-10, EGFR, EGF, FGFR4, CCDN1, VEGFR2, VEGF, CXCR2, IL-8, MMP3, ICAM1, ERCC1, RAD51 and XRCC3) would predict disease-free-survival (DFS), Overall survival (OS) and toxicity in the INT0144 trial, which was designed to investigate...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Bohanes, Pierre, Rankin, Cathryn J., Blanke, Charles D., Winder, Thomas, Ulrich, Cornelia M., Smalley, Stephen R., Rich, Tyvin A., Martensen, James A., Benson, Al B., Mayer, Robert J., Cripps, Christine M., Danenberg, Kathleen, Makar, Karen W., Zhang, Wu, Benedetti, Jacqueline K., Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566931/
https://ncbi.nlm.nih.gov/pubmed/25589620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0857
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