Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum

The common γ molecule (γc) is a shared signaling receptor subunit used by six γc-cytokines. These cytokines play crucial roles in the differentiation of the mature immune system and are involved in many human diseases. Moreover, recent studies suggest that multiple γc-cytokines are pathogenically in...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Biol Chem
Main Authors: Nata, Toshie, Basheer, Asjad, Cocchi, Fiorenza, van Besien, Richard, Massoud, Raya, Jacobson, Steven, Azimi, Nazli, Tagaya, Yutaka
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566211/
https://ncbi.nlm.nih.gov/pubmed/26183780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661074
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla