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Targeting the Binding Interface on a Shared Receptor Subunit of a Cytokine Family Enables the Inhibition of Multiple Member Cytokines with Selectable Target Spectrum

The common γ molecule (γc) is a shared signaling receptor subunit used by six γc-cytokines. These cytokines play crucial roles in the differentiation of the mature immune system and are involved in many human diseases. Moreover, recent studies suggest that multiple γc-cytokines are pathogenically in...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Nata, Toshie, Basheer, Asjad, Cocchi, Fiorenza, van Besien, Richard, Massoud, Raya, Jacobson, Steven, Azimi, Nazli, Tagaya, Yutaka
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566211/
https://ncbi.nlm.nih.gov/pubmed/26183780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661074
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