A Pneumocyte–Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis

Lipid-laden macrophages, or “foam cells,” are observed in the lungs of patients with fibrotic lung disease, but their contribution to disease pathogenesis remains unexplored. Here, we demonstrate that fibrosis induced by bleomycin, silica dust, or thoracic radiation promotes early and sustained accu...

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Bibliografske podrobnosti
izdano v:Am J Respir Cell Mol Biol
Main Authors: Romero, Freddy, Shah, Dilip, Duong, Michelle, Penn, Raymond B., Fessler, Michael B., Madenspacher, Jennifer, Stafstrom, William, Kavuru, Mani, Lu, Bo, Kallen, Caleb B., Walsh, Kenneth, Summer, Ross
Format: Artigo
Jezik:Inglês
Izdano: American Thoracic Society 2015
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566113/
https://ncbi.nlm.nih.gov/pubmed/25409201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0343OC
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