A Pneumocyte–Macrophage Paracrine Lipid Axis Drives the Lung toward Fibrosis

Lipid-laden macrophages, or “foam cells,” are observed in the lungs of patients with fibrotic lung disease, but their contribution to disease pathogenesis remains unexplored. Here, we demonstrate that fibrosis induced by bleomycin, silica dust, or thoracic radiation promotes early and sustained accu...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Romero, Freddy, Shah, Dilip, Duong, Michelle, Penn, Raymond B., Fessler, Michael B., Madenspacher, Jennifer, Stafstrom, William, Kavuru, Mani, Lu, Bo, Kallen, Caleb B., Walsh, Kenneth, Summer, Ross
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566113/
https://ncbi.nlm.nih.gov/pubmed/25409201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0343OC
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