Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). We have previously shown that Notch3 is up...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Smith, Kimberly A., Voiriot, Guillaume, Tang, Haiyang, Fraidenburg, Dustin R., Song, Shanshan, Yamamura, Hisao, Yamamura, Aya, Guo, Qiang, Wan, Jun, Pohl, Nicole M., Tauseef, Mohammad, Bodmer, Rolf, Ocorr, Karen, Thistlethwaite, Patricia A., Haddad, Gabriel G., Powell, Frank L., Makino, Ayako, Mehta, Dolly, Yuan, Jason X.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566064/
https://ncbi.nlm.nih.gov/pubmed/25569851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0235OC
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