Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). We have previously shown that Notch3 is up...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Main Authors: Smith, Kimberly A., Voiriot, Guillaume, Tang, Haiyang, Fraidenburg, Dustin R., Song, Shanshan, Yamamura, Hisao, Yamamura, Aya, Guo, Qiang, Wan, Jun, Pohl, Nicole M., Tauseef, Mohammad, Bodmer, Rolf, Ocorr, Karen, Thistlethwaite, Patricia A., Haddad, Gabriel G., Powell, Frank L., Makino, Ayako, Mehta, Dolly, Yuan, Jason X.-J.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2015
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566064/
https://ncbi.nlm.nih.gov/pubmed/25569851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0235OC
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