Pathologic Regulation of Collagen I by an Aberrant Protein Phosphatase 2A/Histone Deacetylase C4/MicroRNA-29 Signal Axis in Idiopathic Pulmonary Fibrosis Fibroblasts

Idiopathic pulmonary fibrosis (IPF) is characterized by the relentless expansion of fibroblasts depositing type I collagen within the alveolar wall and obliterating the alveolar airspace. MicroRNA (miR)-29 is a potent regulator of collagen expression. In IPF, miR-29 levels are low, whereas type I co...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Khalil, Wajahat, Xia, Hong, Bodempudi, Vidya, Kahm, Judy, Hergert, Polla, Smith, Karen, Peterson, Mark, Parker, Matthew, Herrera, Jeremy, Bitterman, Peter B., Henke, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566061/
https://ncbi.nlm.nih.gov/pubmed/25612003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0150OC
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