A Novel Microtubule-Disrupting Agent Induces Endoplasmic Reticular Stress-Mediated Cell Death in Human Hepatocellular Carcinoma Cells

Here, we present evidence of a novel microtubule-disrupting agent, N-deacetyl-N-(chromone-2-carbonyl)-thiocolchicine (TCD), exhibiting potent antitumor activity (with IC(50) values in the nanomolar range) against hepatocellular carcinoma cell lines. Cell cycle analysis revealed that TCD induced G(2)...

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Udgivet i:PLoS One
Main Authors: Ho, Chun-Te, Chang, Yu-Jia, Yang, Li-Xi, Wei, Po-Li, Liu, Tsan-Zon, Liu, Jun-Jen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565632/
https://ncbi.nlm.nih.gov/pubmed/26355599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136340
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