The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death

Adhesion of leukemic cells to vascular cells may confer resistance to chemotherapeutic agents. We hypothesized that disruption of leukemic cell cytoskeletal stability and interference with vascular cell interactions would promote leukemic cell death. We demonstrate that low and nontoxic doses of mic...

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Detalhes bibliográficos
Main Authors: Petit, Isabelle, Karajannis, Matthias A., Vincent, Loic, Young, Lauren, Butler, Jason, Hooper, Andrea T., Shido, Koji, Steller, Hermann, Chaplin, David J., Feldman, Eric, Rafii, Shahin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234044/
https://ncbi.nlm.nih.gov/pubmed/18024794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-089219
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