The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death

Adhesion of leukemic cells to vascular cells may confer resistance to chemotherapeutic agents. We hypothesized that disruption of leukemic cell cytoskeletal stability and interference with vascular cell interactions would promote leukemic cell death. We demonstrate that low and nontoxic doses of mic...

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Bibliografiske detaljer
Main Authors: Petit, Isabelle, Karajannis, Matthias A., Vincent, Loic, Young, Lauren, Butler, Jason, Hooper, Andrea T., Shido, Koji, Steller, Hermann, Chaplin, David J., Feldman, Eric, Rafii, Shahin
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234044/
https://ncbi.nlm.nih.gov/pubmed/18024794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-089219
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