Loss of Heterozygosity at the CYP2D6 Locus in Breast Cancer: Implications for Germline Pharmacogenetic Studies

BACKGROUND: Controversy exists regarding the impact of CYP2D6 genotype on tamoxifen responsiveness. We examined loss of heterozygosity (LOH) at the CYP2D6 locus and determined its impact on genotyping error when tumor tissue is used as a DNA source. METHODS: Genomic tumor data from the adjuvant and...

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Publicado en:J Natl Cancer Inst
Main Authors: Goetz, Matthew P., Sun, James X., Suman, Vera J., Silva, Grace O., Perou, Charles M., Nakamura, Yusuke, Cox, Nancy J., Stephens, Philip J., Miller, Vincent A., Ross, Jeffrey S., Chen, David, Safgren, Stephanie L., Kuffel, Mary J., Ames, Matthew M., Kalari, Krishna R., Gomez, Henry L., Gonzalez-Angulo, Ana M., Burgues, Octavio, Brauch, Hiltrud B., Ingle, James N., Ratain, Mark J., Yelensky, Roman
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565524/
https://ncbi.nlm.nih.gov/pubmed/25490892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju401
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