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Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.

Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. At the histologic level, RCs develop through multiple stages from early preneoplastic lesions (e.g., atypical tubul...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Hino, O, Klein-Szanto, A J, Freed, J J, Testa, J R, Brown, D Q, Vilensky, M, Yeung, R S, Tartof, K D, Knudson, A G
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1993
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45653/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8419937/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.1.327
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