Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness

In cancer metastasis and other physiological processes, cells migrate through the three-dimensional (3D) extracellular matrix of connective tissue and must overcome the steric hindrance posed by pores that are smaller than the cells. It is currently assumed that low cell stiffness promotes cell migr...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Lautscham, Lena A., Kämmerer, Christoph, Lange, Janina R., Kolb, Thorsten, Mark, Christoph, Schilling, Achim, Strissel, Pamela L., Strick, Reiner, Gluth, Caroline, Rowat, Amy C., Metzner, Claus, Fabry, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564685/
https://ncbi.nlm.nih.gov/pubmed/26331248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.07.025
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