Stat1-Deficient Mice Are Not an Appropriate Model for Efficacy Testing of Recombinant Vesicular Stomatitis Virus–Based Filovirus Vaccines

Stat1(−/−) mice lack a response to interferon α, β, and γ, allowing for replication of nonadapted wild-type (wt) Ebolavirus and Marburgvirus. We sought to establish a mouse model for efficacy testing of live attenuated recombinant vesicular stomatitis virus (rVSV)–based filovirus vaccine vectors usi...

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Bibliographic Details
Published in:J Infect Dis
Main Authors: Marzi, Andrea, Kercher, Lisa, Marceau, Joshua, York, Anthony, Callsion, Julie, Gardner, Donald J., Geisbert, Thomas W., Feldmann, Heinz
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Ebola and Marburg Viruses-Research, Outbreak Management, Epidemiology and Ecology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564544/
https://ncbi.nlm.nih.gov/pubmed/26022440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv188
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