Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects

BACKGROUND: Inhaled LPS causes neutrophilic airway inflammation in healthy subjects. We compared the effects of p38 MAPK inhibitors and fluticasone propionate on the LPS response. METHODS: Three randomised, double-blind, placebo-controlled, single dose crossover studies were performed. Active treatm...

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Vydáno v:Eur J Clin Pharmacol
Hlavní autoři: Singh, Dave, Siew, Leonard, Christensen, Jared, Plumb, Jonathan, Clarke, Graham W., Greenaway, Steve, Perros-Huguet, Christelle, Clarke, Nick, Kilty, Iain, Tan, Lisa
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
Témata:
Clinical Trial
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564450/
https://ncbi.nlm.nih.gov/pubmed/26265232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-015-1920-1
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