Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells

We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells. Western blot analysis showed silibinin inhibits iNOS gene expression. RT-PCR s...

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Hoofdauteurs: Youn, Cha Kyung, Park, Seon Joo, Lee, Min Young, Cha, Man Jin, Kim, Ok Hyeun, You, Ho Jin, Chang, In Youp, Yoon, Sang Pil, Jeon, Young Jin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Korean Society of Applied Pharmacology 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3819897/
https://ncbi.nlm.nih.gov/pubmed/24244809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2013.044
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