Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer

Strategies aimed at invoking synaptic plasticity have therapeutic potential for several neurological conditions. The human retinal synaptic disease X-linked retinoschisis (XLRS) is characterized by impaired visual signal transmission through the retina and progressive visual acuity loss, and mice la...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ou, Jingxing, Vijayasarathy, Camasamudram, Ziccardi, Lucia, Chen, Shan, Zeng, Yong, Marangoni, Dario, Pope, Jodie G., Bush, Ronald A., Wu, Zhijian, Li, Wei, Sieving, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563692/
https://ncbi.nlm.nih.gov/pubmed/26098217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI81380
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