Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice

Bruton’s Tyrosine Kinase (BTK) and IL-2 Inducible T-cell Kinase (ITK) are enzymes responsible for the phosphorylation and activation of downstream effectors in the B-cell receptor (BCR) signaling and T cell receptor (TCR) signaling pathways, respectively. Ibrutinib is an FDA-approved potent inhibito...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schutt, Steven D., Fu, Jianing, Nguyen, Hung, Bastian, David, Heinrichs, Jessica, Wu, Yongxia, Liu, Chen, McDonald, Daniel G., Pidala, Joseph, Yu, Xue-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562702/
https://ncbi.nlm.nih.gov/pubmed/26348529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137641
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