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T-bet is Critical for the Development of Acute Graft-versus-Host Disease through Controlling T-Cell Differentiation and Function
T-bet is a master regulator for IFN-γ production and Th1 differentiation. We evaluated the roles of T-bet and IFN-γ in T-cell responses in acute graft-versus-host disease (GVHD) and found that T-bet(−/−) T cells induced significantly less GVHD compared to WT or IFN-γ(−/−) counterparts in both MHC-mi...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314960/ https://ncbi.nlm.nih.gov/pubmed/25404360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401618 |
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