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On the Function and Homeostasis of PCSK9: Reciprocal Interaction with LDLR and Additional Lipid Effects

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulatory ligand that terminates the lifecycle of the low-density lipoprotein (LDL) receptor (LDLR) thus affecting plasma LDL-cholesterol (LDL-C) levels. Recent evidence shows that in addition to the straightforward mechanism of action, th...

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Bibliografiske detaljer
Udgivet i:Atherosclerosis
Main Authors: Tavori, Hagai, Rashid, Shirya, Fazio, Sergio
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4562333/
https://ncbi.nlm.nih.gov/pubmed/25544176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2014.12.017
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