Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor

AIM: Glyoxalase I (GLOI), a glutathione (GSH)-dependent enzyme, is overexpressed in tumor cells and related to multi-drug resistance in chemotherapy, making GLOI inhibitors as potential anti-tumor agents. But the most studied GSH analogs exhibit poor pharmacokinetic properties. The aim of this study...

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Publicado no:Acta Pharmacol Sin
Main Authors: Zhang, Hong, Huang, Qiang, Zhai, Jing, Zhao, Yi-ning, Zhang, Li-ping, Chen, Yun-yun, Zhang, Ren-wei, Li, Qing, Hu, Xiao-peng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561975/
https://ncbi.nlm.nih.gov/pubmed/26279158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.59
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