18α-Glycyrrhetinic acid monoglucuronide as an anti-inflammatory agent through suppression of the NF-κB and MAPK signaling pathway

Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Li, Bo, Yang, Yongan, Chen, Liuzeng, Chen, Shichao, Zhang, Jing, Tang, Wenjian
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071922/
https://ncbi.nlm.nih.gov/pubmed/30108861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00210f
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