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Noninvasive Prenatal Screening for Genetic Diseases Using Massively Parallel Sequencing of Maternal Plasma DNA

The identification of cell-free fetal DNA (cffDNA) in maternal plasma in 1997 heralded the most significant change in obstetric care for decades, with the advent of safer screening and diagnosis based on analysis of maternal blood. Here, we describe how the technological advances offered by next-gen...

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Publicat a:Cold Spring Harb Perspect Med
Autors principals: Chitty, Lyn S., Lo, Y. M. Dennis
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561399/
https://ncbi.nlm.nih.gov/pubmed/26187875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a023085
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