Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice

Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a transgenic mouse expressi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Fiume, Giuseppe, Scialdone, Annarita, Albano, Francesco, Rossi, Annalisa, Maria Tuccillo, Franca, Rea, Domenica, Palmieri, Camillo, Caiazzo, Elisabetta, Cicala, Carla, Bellevicine, Claudio, Falcone, Cristina, Vecchio, Eleonora, Pisano, Antonio, Ceglia, Simona, Mimmi, Selena, Iaccino, Enrico, Laurentiis, Annamaria de, Pontoriero, Marilena, Agosti, Valter, Troncone, Giancarlo, Mignogna, Chiara, Palma, Giuseppe, Arra, Claudio, Mallardo, Massimo, Maria Buonaguro, Franco, Scala, Giuseppe, Quinto, Ileana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561375/
https://ncbi.nlm.nih.gov/pubmed/26343909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13864
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