Co-localization of a CD1d-binding glycolipid with a radiation-attenuated sporozoite vaccine in LN-resident DCs for a robust adjuvant effect

A CD1d-binding glycolipid, α-Galactosylceramide (αGalCer), activates invariant natural killer T (iNKT) cells and acts as an adjuvant. We previously identified a fluorinated phenyl ring-modified αGalCer analog, 7DW8-5, displaying nearly 100-fold stronger CD1d binding affinity. In the present study, 7...

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Publicado en:J Immunol
Main Authors: Li, Xiangming, Kawamura, Akira, Andrews, Chasity D., Miller, Jessica L., Wu, Douglass, Tsao, Tiffany, Zhang, Min, Oren, Deena, Padte, Neal N., Porcelli, Steven A., Wong, Chi-Huey, Kappe, Stefan H. I., Ho, David D., Tsuji, Moriya
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561196/
https://ncbi.nlm.nih.gov/pubmed/26254338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1403017
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