IL-3 maintains activation of the P90S6K/RPS6 pathway and increases translation in human eosinophils()

IL-5 is a major therapeutic target to reduce eosinophilia. However, all of the eosinophil-activating cytokines IL-5, IL-3, and GM-CSF are typically present in atopic diseases including allergic asthma. Due to the functional redundancy of these 3 cytokines on eosinophils and the loss of IL-5 receptor...

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發表在:J Immunol
Main Authors: Esnault, Stephane, Kelly, Elizabeth A.B., Shen, Zhong-Jian, Johansson, Mats W., Malter, James S., Jarjour, Nizar N.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561194/
https://ncbi.nlm.nih.gov/pubmed/26276876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500871
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