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PGC-1/spargel counteracts high fat diet-induced obesity and cardiac lipotoxicity downstream of TOR and Brummer ATGL lipase

Obesity and metabolic syndrome are associated with an increased risk for lipotoxic cardiomyopathy, which is strongly correlated with excessive accumulation of lipids in the heart. Obesity- and type 2 diabetes-related disorders have been linked to altered expression of the transcriptional cofactor PG...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Diop, Soda Balla, Bisharat-Kernizan, Jumana, Birse, Ryan Tyge, Oldham, Sean, Ocorr, Karen, Bodmer, Rolf
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560688/
https://ncbi.nlm.nih.gov/pubmed/25753422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.02.022
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