HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance

Why breast cancers become resistant to tamoxifen despite continued expression of the estrogen receptor alpha (ERα) and what factors are responsible for high HER2 expression in these tumors remains an enigma. HOXB7 ChIP analysis followed by validation showed that HOXB7 physically interacts with ERα,...

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Vydáno v:Cancer Discov
Hlavní autoři: Jin, Kideok, Park, Sunju, Teo, Wei Wen, Korangath, Preethi, Cho, Sean Soonweng, Yoshida, Takahiro, Győrffy, Balázs, Goswami, Chirayu Pankaj, Nakshatri, Harikrishna, Cruz, Leigh-Ann, Zhou, Weiqiang, Ji, Hongkai, Su, Ying, Ekram, Muhammad, Wu, Zhengsheng, Zhu, Tao, Polyak, Kornelia, Sukumar, Saraswati
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560624/
https://ncbi.nlm.nih.gov/pubmed/26180042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0090
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