HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance

Why breast cancers become resistant to tamoxifen despite continued expression of the estrogen receptor alpha (ERα) and what factors are responsible for high HER2 expression in these tumors remains an enigma. HOXB7 ChIP analysis followed by validation showed that HOXB7 physically interacts with ERα,...

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Publicado no:Cancer Discov
Main Authors: Jin, Kideok, Park, Sunju, Teo, Wei Wen, Korangath, Preethi, Cho, Sean Soonweng, Yoshida, Takahiro, Győrffy, Balázs, Goswami, Chirayu Pankaj, Nakshatri, Harikrishna, Cruz, Leigh-Ann, Zhou, Weiqiang, Ji, Hongkai, Su, Ying, Ekram, Muhammad, Wu, Zhengsheng, Zhu, Tao, Polyak, Kornelia, Sukumar, Saraswati
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560624/
https://ncbi.nlm.nih.gov/pubmed/26180042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0090
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