HOXB13 Mediates Tamoxifen Resistance and Invasiveness in Human Breast Cancer by Suppressing ERα and Inducing IL-6 Expression

Most breast cancers expressing the estrogen receptor α (ERα) are treated successfully with the receptor antagonist tamoxifen (TAM), but many of these tumors recur. Elevated expression of the homeodomain transcription factor HOXB13 correlates with TAM-resistance in ERα-positive (ER+) breast cancer, b...

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Autors principals: Shah, Nilay, Jin, Kideok, Cruz, Leigh-Ann, Park, Sunju, Sadik, Helen, Cho, Soonweng, Goswami, Chirayu Pankaj, Nakshatri, Harikrishna, Gupta, Rajnish, Chang, Howard Y., Zhang, Zhe, Cimino-Mathews, Ashley, Cope, Leslie, Umbricht, Christopher, Sukumar, Saraswati
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967590/
https://ncbi.nlm.nih.gov/pubmed/23832664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1178
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