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Increased excitability of medium-sized dorsal root ganglion neurons by prolonged interleukin-1β exposure is K(+) channel dependent and reversible

Chronic constriction injury of rat sciatic nerve promotes signs of neuropathic pain. This is associated with an increase in the level of interleukin 1β (IL-1β) in primary afferents that peaks at 7 days. This initial cytokine exposure has been proposed to trigger an enduring alteration in neuronal ph...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Stemkowski, Patrick L, Noh, Myung-chul, Chen, Yishen, Smith, Peter A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560594/
https://ncbi.nlm.nih.gov/pubmed/26110238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP270905
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