Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration

The expression of soluble growth and survival promoting factors by neural precursor cells (NPCs) is suggested to be a prominent mechanism underlying the protective and regenerative effects of these cells after transplantation. Nevertheless, how and to what extent specific NPC-expressed factors contr...

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Udgivet i:PLoS One
Main Authors: Madhavan, Lalitha, Daley, Brian F., Davidson, Beverly L., Boudreau, Ryan L., Lipton, Jack W., Cole-Strauss, Allyson, Steece-Collier, Kathy, Collier, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560385/
https://ncbi.nlm.nih.gov/pubmed/26340267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137136
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