Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism

In addition to alleviating depression, long-term adaptive changes induced by antidepressants may regulate neural plasticity in the diseased brain, providing symptomatic and disease-modifying effects in Parkinson's disease. The present study investigated whether chronic treatment with a frequent...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Paumier, Katrina L, Sortwell, Caryl E, Madhavan, Lalitha, Terpstra, Brian, Celano, Stephanie L, Green, Joshua J, Imus, Nastassja M, Marckini, Nathan, Daley, Brian, Steece-Collier, Kathy, Collier, Timothy J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4330501/
https://ncbi.nlm.nih.gov/pubmed/25267343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.262
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