AFAP1 Is a Novel Downstream Mediator of TGF-β1 for CCN2 Induction in Osteoblasts

BACKGROUND: CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function. CCN2 is induced by TGF-β1 and acts as a mediator of TGF-β1 induced matrix production in osteoblasts and Src is required for CCN2 induction by TGF-β1; however, the molecular mechanisms that control...

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Bibliographic Details
Published in:PLoS One
Main Authors: Cho, Youngjin, Silverstein, Rachel, Geisinger, Max T., Martinkovich, Stephen, Corkill, Holly, Cunnick, Jess M., Planey, Sonia L., Arnott, John A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560384/
https://ncbi.nlm.nih.gov/pubmed/26340021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0136712
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