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Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development

Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3’UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM) is the most severe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Michel, Lise, Huguet-Lachon, Aline, Gourdon, Geneviève
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560382/
https://ncbi.nlm.nih.gov/pubmed/26339785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137620
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