Novel STAT3 mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in Hyper-IgE syndrome

BACKGROUND: Hyper-IgE Syndrome (HIES) is a rare, autosomal dominant (AD) immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses, pneumonia with pneumatocele formation, Candida infections, and skeletal/connective tissue abnormalities. Recently it was shown that heterozygous ST...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Renner, Ellen D, Rylaarsdam, Stacey, Aňover-Sombke, Stephanie, Rack, Anita L, Reichenbach, Janine, Carey, John C., Zhu, Qili, Jansson, Annette F, Barboza, Julia, Schimke, Lena F, Leppert, Mark F., Getz, Melissa M., Seger, Reinhard A, Hill, Harry R, Belohradsky, Bernd H, Torgerson, Troy R, Ochs, Hans D
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560358/
https://ncbi.nlm.nih.gov/pubmed/18602572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2008.04.037
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