Novel STAT3 mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in Hyper-IgE syndrome

BACKGROUND: Hyper-IgE Syndrome (HIES) is a rare, autosomal dominant (AD) immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses, pneumonia with pneumatocele formation, Candida infections, and skeletal/connective tissue abnormalities. Recently it was shown that heterozygous ST...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Renner, Ellen D, Rylaarsdam, Stacey, Aňover-Sombke, Stephanie, Rack, Anita L, Reichenbach, Janine, Carey, John C., Zhu, Qili, Jansson, Annette F, Barboza, Julia, Schimke, Lena F, Leppert, Mark F., Getz, Melissa M., Seger, Reinhard A, Hill, Harry R, Belohradsky, Bernd H, Torgerson, Troy R, Ochs, Hans D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560358/
https://ncbi.nlm.nih.gov/pubmed/18602572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2008.04.037
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