Novel STAT3 mutations, reduced TH17 cell numbers, and variably defective STAT3 phosphorylation in Hyper-IgE syndrome

BACKGROUND: Hyper-IgE Syndrome (HIES) is a rare, autosomal dominant (AD) immunodeficiency characterized by eczema, Staphylococcus aureus skin abscesses, pneumonia with pneumatocele formation, Candida infections, and skeletal/connective tissue abnormalities. Recently it was shown that heterozygous ST...

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Published in:J Allergy Clin Immunol
Main Authors: Renner, Ellen D, Rylaarsdam, Stacey, Aňover-Sombke, Stephanie, Rack, Anita L, Reichenbach, Janine, Carey, John C., Zhu, Qili, Jansson, Annette F, Barboza, Julia, Schimke, Lena F, Leppert, Mark F., Getz, Melissa M., Seger, Reinhard A, Hill, Harry R, Belohradsky, Bernd H, Torgerson, Troy R, Ochs, Hans D
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560358/
https://ncbi.nlm.nih.gov/pubmed/18602572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2008.04.037
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