Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

INTRODUCTION: Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury in the central nervous system. Increasing evidence indicates that lecticans may also play a role in synaptic plasticity related...

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Foilsithe in:Acta Neuropathol Commun
Main Authors: Howell, Matthew D., Bailey, Lauren A., Cozart, Michael A., Gannon, Brenda M., Gottschall, Paul E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559967/
https://ncbi.nlm.nih.gov/pubmed/26337292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0233-z
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