Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling

The target of rapamycin complex 1 (TORC1) integrates various hormonal and nutrient signals to regulate cell growth, proliferation, and differentiation. Amino acid-dependent activation of TORC1 is mediated via the yeast EGO complex (EGOC) consisting of Gtr1, Gtr2, Ego1, and Ego3. Here, we identify th...

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Bibliografiska uppgifter
I publikationen:Cell Res
Huvudupphovsmän: Powis, Katie, Zhang, Tianlong, Panchaud, Nicolas, Wang, Rong, Virgilio, Claudio De, Ding, Jianping
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2015
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559812/
https://ncbi.nlm.nih.gov/pubmed/26206314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.86
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