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Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer

Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. The physiological function of estrogen is primarily mediated by estrogen receptor alpha, encoded by ESR1. Consequently, several studies have investigated...

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Xuất bản năm:Endocr Relat Cancer
Những tác giả chính: O’Mara, Tracy A, Glubb, Dylan M, Painter, Jodie N, Cheng, Timothy, Dennis, Joe, Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Shah, Mitul, Ahmed, Shahana, Healey, Catherine S, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley, Fasching, Peter A, Hein, Alexander, Beckmann, Matthias W, Ekici, Arif B, Hall, Per, Czene, Kamila, Darabi, Hatef, Li, Jingmei, Dürst, Matthias, Runnebaum, Ingo, Hillemanns, Peter, Dörk, Thilo, Lambrechts, Diether, Depreeuw, Jeroen, Annibali, Daniela, Amant, Frederic, Zhao, Hui, Goode, Ellen L, Dowdy, Sean C, Fridley, Brooke L, Winham, Stacey J, Salvesen, Helga B, Njølstad, Tormund S, Trovik, Jone, Werner, Henrica MJ, Tham, Emma, Liu, Tao, Mints, Miriam, Bolla, Manjeet K, Michailidou, Kyriaki, Tyrer, Jonathan P, Wang, Qin, Hopper, John L, Peto, Julian, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Pharoah, Paul D P, Dunning, Alison M, Tomlinson, Ian, Easton, Douglas F, Thompson, Deborah J, Spurdle, Amanda B
Định dạng: Artigo
Ngôn ngữ:Inglês
Được phát hành: 2015
Những chủ đề:
Truy cập trực tuyến:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559752/
https://ncbi.nlm.nih.gov/pubmed/26330482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-15-0319
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