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Enzyme-responsive doxorubicin release from dendrimer nanoparticles for anticancer drug delivery
BACKGROUND: Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol) (MPEG)-doxorubicin (DOX) conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting. METHODS: Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic...
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| Pubblicato in: | Int J Nanomedicine |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Dove Medical Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4559238/ https://ncbi.nlm.nih.gov/pubmed/26357473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S87145 |
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