Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

BACKGROUND: Inflammation and oxidative stress play critical roles in patients with chronic obstructive pulmonary disease (COPD). Mitochondrial oxidative stress might be involved in driving the oxidative stress–induced pathology. OBJECTIVE: We sought to determine the effects of oxidative stress on mi...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Wiegman, Coen H., Michaeloudes, Charalambos, Haji, Gulammehdi, Narang, Priyanka, Clarke, Colin J., Russell, Kirsty E., Bao, Wuping, Pavlidis, Stelios, Barnes, Peter J., Kanerva, Justin, Bittner, Anton, Rao, Navin, Murphy, Michael P., Kirkham, Paul A., Chung, Kian Fan, Adcock, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mosby 2015
Assuntos:
Mechanisms of Allergy and Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559140/
https://ncbi.nlm.nih.gov/pubmed/25828268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.01.046
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