Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

BACKGROUND: Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system (CNS). It is widely accepted that inflammatory cells play major roles in the pathogenesis of MS, possibly through the use of serine protease granzyme B (GrB) secreted from th...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Haile, Yohannes, Carmine-Simmen, Katia, Olechowski, Camille, Kerr, Bradley, Bleackley, R. Chris, Giuliani, Fabrizio
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558826/
https://ncbi.nlm.nih.gov/pubmed/26337722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0376-7
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