Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants

Objective: Canagliflozin, a sodium-glucose co-transporter 2 inhibitor, approved for the treatment of type-2 diabetes mellitus (T2DM), is metabolized by uridine diphosphate-glucuronosyltransferases (UGT) 1A9 and UGT2B4, and is a substrate of P-glycoprotein (P-gp). Canagliflozin exposures may be affec...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Clin Pharmacol Ther
Auteurs principaux: Devineni, Damayanthi, Vaccaro, Nicole, Murphy, Joe, Curtin, Christopher, Mamidi, Rao N.V.S., Weiner, Sveta, Wang, Shean-Sheng, Ariyawansa, Jay, Stieltjes, Hans, Wajs, Ewa, Di Prospero, Nicholas A., Rothenberg, Paul
Format: Artigo
Langue:Inglês
Publié: Dustri-Verlag Dr. Karl Feistle 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558628/
https://ncbi.nlm.nih.gov/pubmed/25407255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5414/CP202158
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