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Regions Outside of Conserved PxxPxR Motifs Drive the High Affinity Interaction of GRB2 with SH3 Domain Ligands
SH3 domains are evolutionarily conserved protein interaction domains that control nearly all cellular processes in eukaryotes. The current model is that most SH3 domains bind discreet PxxPxR motifs with weak affinity and relatively low selectivity. However, the interactions of full-length SH3 domain...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4558342/ https://ncbi.nlm.nih.gov/pubmed/26079855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.06.002 |
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