Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade

PURPOSE: Blocking the immunosuppressive PD-1/PD-L1 pathway has anti-tumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response. We previously found that IFNG (interferon-gamma) was over-expressed by TILs in P...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Taube, Janis M., Young, Geoffrey D., McMiller, Tracee L., Chen, Shuming, Salas, January T., Pritchard, Theresa S., Xu, Haiying, Meeker, Alan K., Fan, Jinshui, Cheadle, Chris, Berger, Alan E., Pardoll, Drew M., Topalian, Suzanne L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558237/
https://ncbi.nlm.nih.gov/pubmed/25944800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0244
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